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Foraminifera and Cercozoa are related in actin phylogeny: two orphans find a home?

In recent years, the increased sampling of protein-coding genes from diverse eukaryotes has revealed that many aspects of each gene tree are at odds with other phylogenies. This has led to the belief that each gene tree has unique strengths and weaknesses, suggesting that an accurate picture of eukaryotic relationships will be achieved only through comparative phylogeny using several different ...

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Nuclear Receptors: Lonesome orphans

Nuclear receptors typically bind to DNA as homodimers or heterodimers, but increasing numbers of orphan receptors have been identified that bind DNA as monomers.

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Therapeutic orphans: European perspective.

There are several factors to be considered when facing the problem of therapeutic orphans. First, there is the scientific one. We are all convinced that there is much need for more data concerning the use of drugs in children, infants, and neonates. Second, there is a regulatory factor involving political and technical institutions. Finally, we have to consider the economic interest of the phar...

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Editorial Comment: Therapeutic Orphans

By an odd and unfortunate twist of fate, infants and children are becoming “therapeutic or pharmaceutical orphans.”1 Since 1962 they have been denied the use of many new drugs. The Drug Laws of 1962 had their inception following a pediatric tragedy—the thalidomide catastrophe. The laws of 1938 followed another which resulted from the use of a pediatric dosage form, “elixir” of sulfanilamide. By...

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Orphans in Africa

“In at least one important dimension — school enrollment — orphans are signifi cantly disadvantaged... Although poorer children in Africa are less likely to attend school, the lower enrollment of orphans is not accounted for solely by their lower wealth. Instead, our results suggest that the special disadvantage orphans face is primarily due to their living arrangements. Across a large number o...

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ژورنال

عنوان ژورنال: The Lancet

سال: 1879

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(02)47881-6